|
KMID : 0616120120430010072
|
|
Korean Journal of Pharmacognosy
2012 Volume.43 No. 1 p.72 ~ p.78
|
|
|
Effect of Hot Water Extract of Alnus japonica Steud on the Experimentally-induced Acute Gastritis and Peptic Ulcers in Rats
|
|
Na Chun-Su
Lee Sang-Bum
Kim Jin-Bum
Chung Ha-Sook
Dong Mi-Sook
|
|
|
Abstract
|
|
|
|
Alnus japonica Steud (A. japonica) have long been used in the traditional medicine for gastric disorder, hepatitis and fatty liver in Korea. Antiulcer effects of A. japonica hot water extract (AJ ext) were evaluated by in vitro antibacterial activity against H. pylori, by the inhibitory action against the in vitro gastric H+/K+ -ATPase and using rat models of gastric mucosal damage and gastric ulcer induced by HCl-ethanol, indomethacin, and restraint and water-immersion stress. For the determination of antibacterial activity of AJ ext against H. pylori, the activity of urease which released from H. pylori was measured in culture. AJ ext showed weak antibacterial activity against H. pylori with the growth inhibitions of 37% and 61% by adding final concentrations of 500 and 1000 μg/ml culture, respectively at 24 h. To observe the inhibitory activity of AJ ext against the H+/K+ -ATPase in hog gastric membrane vesicle, IC50 value of AJ ext was 806.3 μg/ml. Pretreatment of AJ ext (200, 500 mg/kg, p.o.) prevented in a dose-dependent manner the acute gastritis in HCl-ethanol model and the formation of gastric ulcer in indomethacin model and restraint and water-immersion stress model. These results suggest that the AJ ext can be used for prevention and treatment of gastric mucosal damage and ulcers induced by various stress.
|
|
|
KEYWORD
|
|
|
H. pyroli, Proton pump inhibition, Antigastric ulcer effects, Gastric mucosal damage, Alnus japonica Steud
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|